Влияние блокаторов вегетативной нервной системы на состояние пародонта крыс

Abstract

ABSTRACT The aim. To determine the periodontium state after oral application of vegetative nervous system blockers. The materials and methods. Adrenoblockers: zokson in dose 0,4 mg/kg, sibazon in dose 1 mg/kg and nicergolin in dose 2 mg/kg were used into rats. Parasympatic blocker atropine in dose 1 mg/kg was used by oral applications gel into rats. The applications made during 30 days. The activities of elastase, lysozyme, catalase and contents of MDA and hyaluronic acid were determined into gum. The activities of alkaline and acid phosphatases and contents of calcium and protein were determined into bone of periodontium. The findings. Adrenoblockers raised the lysozyme activity but reduced the degree of dysbiosis and catalase activity into gum. Adrenoblockers raised the mineralisation activity of periodonte bone and reduced the degree of atrophy alveolar bone. Atropine raised the lysozyme activity into gum and the mineralisation activity into bone, but manifested proinflammation action in periodontum. The conclusion. Adrenoblockers have periodontoprotective effect. Atropine may provoke inflammation into gum. Key words: periodontium, adrenoblockers, atropine, dysbiosis, inflammation, lysozyme, mineralisation activity of bone