Quantitative Evaluation Of Cd34 Immunohistochemical Expression In The Placenta In Pregnant Women With Covid-19

Abstract

Coronavirus (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. SARS-CoV-2 affects organs whose cells demonstrate a high level of expression of angiotensin-converting enzyme 2 (ACE2). The action of SARS-CoV-2 leads to necrotic and apoptotic changes in the syncytiotrophoblast and in the endothelium of chorionic villous vessels despite protective mechanisms against vertical transmission, including decreased activity (coexpression) and concentration of angiotensin-converting enzyme type II (ACE2) in the placenta.