Investigation of off-target effects of known bioactive molecules using the swiss targetpredictio program (sib swiss institute of bioinformatics) using the example of 5-substituted uracils

Abstract

The relevance of the search for previously undescribed pharmacological properties of uracil derivatives using the Swiss TargetPredictio program (SIB Swiss Institute of Bioinformatics) is due to their "privileged" chemical structure, namely: polyfunctionality, the presence of pharmacophoric groups, bioisosteric modification of molecules, which opens up wide opportunities for further chemical modification of molecules with a wide range of pharmacological properties and off-target effects.