Investigation of the purity of the active ingredient oxaliplatin (substance) by hplc

Abstract

Oxaliplatin (Eloxatin, Sanofi-Synthelabo) is the first anticancer drug developed on the basis of Platinum. It has been approved for the treatment of colorectal cancer, which is the leading cause of cancer death in the world. Oxaliplatin has a nomenclature systematic name for IUPAC - (trans-R, R-cyclohexane-1,2-diamine) oxalatoplatinum. Oxaliplatin has demonstrated efficacy in many cancer cell lines and components, including some that are largely resistant to cisplatin and carboplatin. Oxaliplatin belongs to toxic medicinal substances. The quality control of this drug should be carried out by high-tech instrumental methods, since the high quality of this medicinal product is important for protecting the health and life of patients. Oxaliplatin is a multifunctional organic compound. Molecules contain pharmacophore groups, functional groups - amino group, hetero cycle, keto group, cyclohexane fragment. Oxaliplatin substance is investigated by chemical methods and instrumental methods.