Development of the hplc technique for studying of the purity of the dextromethorphan hydrobromide substance for the presence of acyclovir inpurity

Abstract

Dextromethorphan is an antitussive. According to the chemical nomenclature, IUPAK is called (+)-3methoxy-17-methyl(9a, 13a, 14a)-morphinan. The basis of the dextromethorphan molecule is the tetracyclic condensed aromatic system of phenanthreneisoquinoline, which contains benzene, cyclohexane and heterocycle rings. This medicine is used to relieve cough without sputum caused by certain respiratory tract infections, but it is not safe or effective for children. To reduce the risk of serious side effects, follow the dosage instructions. Dextromethorphan (DM) is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist. The method of experimental research is the selection and adaptation of chromatographic conditions, the method of preparing solutions for HPLC analysis of the pharmaceutical composition of dextromethorphan with an additional component - acyclovir, which allows protecting its chemical structure from degradation.