Розробка передових матеріалів для гасіння бактеріального кворуму

Abstract

The aim of the work. The study is focused on the synthesis and characterization of molecularly imprinted polymers (MIPs) designed for the selective recognition and removal of signaling molecules involved in bacterial communication. The synthesis of such polymers is achieved by utilizing the key Quorum Sensing (QS) signaling molecule. Among the integrated quorum signals (IQS) involved in the formation of P. aeruginosa biofilms is 2-(2-hydroxyphenyl) thiazole-4-carbaldehyde. Using a structural analog as a template molecule allows for integration into the QS system, while assigning alternative tasks to the biofilms formed by P. aeruginosa.