CLINICAL AND IMMUNOLOGICAL FEATURES OF THE COURSE OF CARIES IN YOUNG PEOPLE WHO HAVE SUFFERED A CORONAVIRUS INFECTION

Abstract

The aim: To establish the clinical and immunological features of the course of caries in young people who have su ered from the coronavirus disease. Materials and methods: The main group consisted of 30 people aged 20,6±2,4 years who su ered from the Covid19 coronavirus infection 6,1±1,2 months ago. All patients underwent a dental and immunological examination. Results: The analysis of the indicators of the dental status revealed the possibility of the existence of a relationship between the signs of the transferred acute viral infection SARS-Cov2 and the development of dental caries, rst, under the condition of reduced caries resistance. In the immune system of the examined patients were found signi cant changes, which de nitely played a pathogenetic role in the development and progression of the carious process. They were manifested by changes of varying degrees of severity, which were both unidirectional and opposite in nature: T-lymphocyte de ciency, in particular, mainly due to T-cytotoxic lymphocytes/suppressors, an increased level of B-lymphocytes and an increased level of activated CD54+ cells of T-lymphocytes. Conclusions: In young people with dental caries who have su ered a coronavirus infection during the last 6 months, the prevalence of caries and its intensity are signi cantly higher than in the comparison group. Violations in the cellular and humoral links of the immune system, which combined with the pro-in- ammatory pro le of the blood serum, the phenomenon of immunotoxicosis, contributed to the further progression of the carious process in the oral cavity. KEY WORDS: caries, coronavirus disease, young age, immunological parameters, cytokines, circulating immune complexes