The peculiarities of the changes of some cardiohemodynamic and microcirculatory indices in conditions of the comorbid course of essential hypertension

Abstract

The peculiarities of cardiohemodynamics, microcirculation, and microvasculature are presented in the article; their correlation with significance of the oxidative stress, the level of antioxidative blood potential and endothelial function in the isolated course of essential hypertension and in conditions of its comorbid ity with duodenal peptic ulcer was carried out. It was established that the presence of the remodeling left ventricle with the unchanged contractile function, and maximal intensity of both resistivity of the periph eral vascular system (р<0.001), and disorders of microcirculation and microvasculature on the perivascu lar, vascular, and intravascular levels (р<0.001) is typical of the patients with the comorbid course of es sential hypertension. The next results showed that manifestations of oxidative stress were the most signifi cant (p<0.001) among the patients with the combinative pathology. The index of the antioxidative ability of blood serum was low in these patients (p<0.001), besides, it had the negative correlation relationship with the index of the total changes of microhemocirculation and microvasculature (r= -0.467; p<0.05). At the same time the index of ristomycin-inducted platelet aggregation as reflection of the changed endothe lial function and a marker of the thrombogenic risk was also the highest in case of the comorbid course of essential hypertension (p <0.001). Besides that, its positive correlation relationship with the index of the total changes of microhemocirculation and microvasculature (r= +0.465; p<0.05) was established. Thus, the significant increase of resistivity of the peripheral part of the vascular system with the pres ence of the significant changes of microcirculation and microvasculature is a typical peculiarity of cardiohemodynamics’ changes in the patients with the comorbid course of essential hypertension with the unchanged contractile function of myocardium of the left ventricle in conditions of its remodeling. Their connection with intensity of the oxidative stress and the endothelial dysfunction reflects a pathogenetic community of the vascular changes’ forming and determines their as a factor of aggravation of the essential hypertension course in conditions of comorbidity