Prediction remission type 2 diabetes mellitus in patents with morbid obesity after laparoscopic gastric bypass

Abstract

Introduction Type 2 diabetes mellitus is common in obesity patients. According to the most recent WHO data, the rate of obesity in Ukraine among men is 17.6% and for women 22.1%. Type 2 diabetes mellitus has 1.3 million population of Ukraine. Objectives The aim was a comparative analysis of two methods - basal levels of C-peptide and DiaRem score for predicting complete remission of type 2 diabetes mellitus in patients with morbid obesity after the laparoscopic gastric bypass surgery. Methods The study included 46 patients with morbid obesity and type 2 diabetes mellitus, who underwent laparoscopic gastric bypass surgery by the method Fobi-Capella Roux-en-Y Gastric Bypass. Results According to ADA criteria 12 months after the laparoscopic gastric bypass surgery complete remission of type 2 diabetes mellitus was achieved in 52.2% of patients. There was no statistically significant difference in both methods of predicting complete remission of type 2 diabetes mellitus, р = 0.8452. When combining methods of analysis of basal levels of C-peptide and DiaRem score in patients with morbid obesity after the laparoscopic gastric bypass surgery, the efficiency of predicting complete remission of diabetes mellitus type 2 significantly increase, AUC = 0,716 (95% CI 0.564 - 0,839), p=0.0206. Conclusion Сombined use of analysis of basal levels of C-peptide and DiaRem score in patients with morbid obesity after laparoscopic gastric bypass surgery is justified and preferred. It can significantly increase the efficiency of predicting complete remission of type 2 diabetes mellitus.