Disorders of neuromediator pool in patiens with multifocal atherosclerosis

Abstract

In 62 patients with multifocal atherosclerosis of men of average age (72.3±3.3) years, blood flow parameters in peripheral arteries, serotonine, histamine, dophamine, beta–endorphins in serum and serotonine in plasma. Found a significant decrease in volumetric blood flow in the arteries carotis interna, mesenterica superior, femoralis communis, tibialis posterior; the levels of serotonine, histamine, dophamine in the serum significantly exceeded their maximum values of almost healthy individuals (control group, n=19), respectively, 4.6, 4.3 and 3.5 times. Taking cilostazol for 12 weeks contributed to a significant (p<0.001) increase in volumetric blood flow in the studied arteries: – in arteries carotis interna by 18.2 %, in arteria mesenterica superior – by 17.8 %, in arteria femoralis communis – by 18.8 %, in arteria tibialis posterior – by 69.4 %, which was accompanied by an improvement in the clinical manifestations of the disease, a significant decrease plasma serotonine level (by 2.9 times; p<0.001) and serotonine (by 39.0 %; p<0.05) and histamine (by 62.1 %; p<0,01) in blood serum, increase beta–endorphin level (by 29.8 %; p<0,01). Serum dophamine levels did not change significantly. The role of neurotransmitters in the course of multifocal atherosclerosis is discussed; the pharmacotherapeutic possibilities of cilostazol are analyzed.