Експресія ендотеліального фактору росту судин у корі великого мозку при порушеннях кровообігу за умов попе-редньої сенсибілізації мозковим антигеном та імунокорекції

Abstract

SUMMARY. Introduction. The vascular endothelial growth factor (VEGF) is a signaling protein that stimulates angiogenesis and performs trophic functions, including in the nervous system. The indicated growth factor affects the processes of development and migration of nerve cells, their survival. The aim of the study – to evaluate changes in the expression of VEGF in the cerebral cortex of circulatory disturbances under conditions of preliminary sensitization by brain antigen and immunocorrection. Results. Observations have shown that sensitization by brain antigen leads to expressive neurodegenerative changes in the sensorimotor cortex and a significant decrease in VEGF expression in neurons. An increase in neurodegenerative and destructive changes in the cerebral cortex and a more significant decrease in the expression of VEGF in neurons characterize embolism of blood vessels of the hemocamcirculatory bed on the background of previous sensitization. In this case, partial recovery after a circulatory disturbance against the background of sensitization occurs more slowly than when the latter do not perform. This can be considering as an immunosupressive suppression of compensatory and restorative processes induced by sensitization. The increase in the number of glial cells observed after the ischemic attack was accompanied by an increase in expression of VEGF. Immunophane significantly reduces the severity of neurodegenerative changes and a decrease in the expression of VEGF caused by both impaired circulations in the cerebral cortex and sensitization. This can be due either to the direct influence of the immunophane, due to its antioxidant properties, and indirectly, due to the relative activation of T-regulatory cells that act as one of the neuroprotective factors that activated after ischemia. Conclusions. Sensitization by brain antigen results in expressive neurodegenerative changes in the sensorimotor cortex and a decrease in VEGF expression in neurons. Embolism of cerebral vessels against the background of previous sensitization, characterized by increased neurodegenerative and destructive changes, an express decrease in VEGF expression and a slowing down of the recovery processes in the cerebral cortex. Immunophane significantly reduces the severity of neurodegenerative changes and a decrease in the expression of VEGF caused by both impaired circulations in cerebral cortex and sensitization.