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Назва: The blood coagulation tests from ischemic stroke patients with or without type 2 diabetes mellitus
Автори: Kravchenko, Olha
Melnyk, Volodymyr
Kostiuk, Oleksandra
Halenova, Tetyana
Raksha, Nataliia
Vovk, Tetyana
Savchuk, Olexiy
Ostapchenko, Liudmyla
Ключові слова: stroke
diabetes mellitus type 2
blood coagulation tests
blood coagulation factors
Дата публікації: 2018
Видавництво: Biomedical Research
Серія/номер: 29 (14): 2938-2943;
Короткий огляд (реферат): Objective: We determined the plasma protein C and coagulation factor X activities, prothrombin, fibrinogen and soluble fibrin monomer complex (SFMC) content and performed the haemostatic screening coagulation time tests under acute ischemic stroke patients with or without type 2 diabetes mellitus, as well as evaluated the significance of biochemical haemostatic markers as predictors of mortality in stroke regardless of diabetes presence. Methods: The baseline data were collected from 87 patients during the admission. Neurological disturbances were assessed using the NIH stroke scale. The functional outcome was estimated using Barthel index. All patients underwent fibrinogen and SFMC (gravimetric methods), prothrombin level (ELISA), plasma protein C and coagulation factor X activity assessment, haemostatic screening coagulation time tests with coagulation analyzer, glucose and glycosylated hemoglobin content and BMI (body mass index) measurements. Results: The conducted research had established the changes of fibrinogen and SFMC levels in both investigated patient groups comparing to the control. The protein C activity was found to be significantly decreased in blood of patients with ischemic stroke with and without diabetes. There were differences in factor X activity change in patients with stroke only comparing with patients with diabetes and stroke and high level of this parameter as well as the increase in SFMC can be regarded as death predictors of stroke independently of diabetes mellitus presence. Conclusion: Among ischemic stroke patients with type 2 diabetes mellitus the differences were more significant for all Time tests of the coagulation cascade, but deviations of haemostatic biochemical markers were more pronounced in ischemic stroke patients without diabetes mellitus.
URI (Уніфікований ідентифікатор ресурсу): http://ir.librarynmu.com/handle/123456789/449
ISSN: 0970-938X
Розташовується у зібраннях:Наукові публікації кафедри неврології

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