Features of local oral immunity in patients with generalized periodontitis and bronchial asthma

Abstract

Abstract The object of the work is to determine the indicators of local immunity in patients with generalized periodontitis (GP) with concomitant BA. To achieve this goal were examined 86 patients with GP aged from 42 to 60 years old. First (1) group (main group) were consisted of 44 people with GP second (II) stage who had a concomitant disease - persistent BA of mild or moderate severity and received as the basic therapy inhaled glucocorticosteroids (ICS), and second (2) group (comparison group) - 42 people with GP on second (II) stage without signs of BA. All patients underwent an immunological examination to determine the level of pro- and anti-inflammatory cytokines by the enzyme immunoassay according to the method of the manufacturer «Pro Con» (Russia) in blood and saliva, the level of circulating immune complexes (CICs) of various molecular weights in serum and saliva, the concentration of IgG, IgA, IgM, IgE immunoglobulins in blood serum and secretory sIgA in saliva, as well as the phagocytic activity of peripheral blood neutrophils and phagocytes in saliva. In patients with GP with concomitant BA were detected a pro-inflammatory changes in the humoral link of the immune system and a decrease in the phagocytic activity of peripheral blood neutrophils.In patients with GP with concomitant BA, changes in the indices of local immunity of the oral fluid are deeper and more specific and are manifested by a pronounced imbalance in the level of T-helper 1 and T-helper 2 derived cytokines, with a predominant content of pro-inflammatory against a significant deficiency of IFN-γ and reduced concentration of SIgA. Keywords: Generalized periodontitis, bronchial asthma, local immunity, circulating immune complexes, cytokines, oral fluid