In vitro activity of prodigiosin isolated from serratia marcescens in combination with polyenes and azoles against candida albicans

Abstract

Fungal infections have reported having dramatically increased in the past decade, and these often occur as systemic infections or as coinfections with other diseases, such as AIDS or cancer, or in patients who are immunocompromised. Unfortunately, in addition to the limited number of antifungal drugs currently available, fungal infections tend to rapidly develop resistance to these drugs. For these reasons, fungal infections now show much higher mortality rates than bacterial infections. Therefore, there is a need to find new compounds and/or alternative methods to get an arsenal against the fungi. Combination therapies using conventional antibiotics and antifungal agents from natural resources fulfill both requirements.