Mechanism of Apoptosis in Development of Glomerular Damage in Nephrotic Children

Abstract

Nephrotic syndrome is a disorder of the glomerular filtration barrier. Podocytes are key link to the filtration mechanism of the glomerular filtration barrier. Here we report that nephrotic patients reveal a high level of podocytes loss. Moreover, this index is dependent to the level of glomerulosclerosis. Podocytes loss is associated with pro-apoptotic markers Bax and caspase-3 activation. We conclude that primary albumin-induced glomerular damage in nephrotic children is podocytes apoptosis activated view mitochondrial pathway and caspase-3 activation. This leads to glomerulosclerosis and kidney function impairment progression.