The prognostic value of hemodynamics indices and biomarkers i-fabp and l-fabp in abdominal compartment syndrome in children with acute neuroinfections

Abstract

Introduction. Infectious diseases in children may be associated with risk factors of developing of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Material and methods. We conducted a retrospective study of cases of ACS in children with infection diseases. Parameters of central and peripheral hemodynamic assessed by echocardiography and doppler ultrasound, and biochemical markers (I-FABP, L-FABP, ALT, bilirubin, creatinine, BUN) were evaluated. Results. Seven cases of ACS and IAH were investigated. Increased abdominal pressure and ACS were associated with significant elevation of serum creatinine (81,37±35,92 mcmol/l amid elevated IAP and 57,14±19,63 in normal IAP, p<0,05), intestinal serum biomarker I-FABP (13,44±4,58 ng/ml amid elevated IAP and 2,65±1,25 amid normal IAP), higher cardiac output (6,0±0,57 l/min/m2 vs 4,3±0,34 l/min/m2 in normal IAP, p<0,05), decreased diastolic blood flow velocity in renal and superior mesenteric arteries (3,4±1,08 cm/s vs 18,7±1,58 cm/s in renal arteries, 5,1±0,87 cm/s vs 17,5±3,90 cm/s in superior mesenteric artery, p<0,05), and elevated peripheral resistance index (RI) in the renal artery (0,92±0,02 vs 0,70±0,02, p<0,05). Conclusion. Assessment of biochemical tests and hemodynamic parameters may be used as additional diagnostic tool for children with ACS.