Будь ласка, використовуйте цей ідентифікатор, щоб цитувати або посилатися на цей матеріал: http://ir.librarynmu.com/handle/123456789/241
Назва: Crosstalk between gut microbiota and antidiabetic drug action
Автори: Kyriachenko, Y.
Falalyeyeva, T.
Korotkyi, O.
Molochek, N.
Kobyliak, N.
Ключові слова: α-glucosidase inhibitors
Type 2 diabetes
Dipeptidyl peptidase-4 inhibitors
Glucagon-like peptide-1 agonists
Gut microbiota
Metformin
Peroxisome proliferator-activated receptors γ agonists
Sodium/glucose cotransporter inhibitors
Дата публікації: 15-бер-2019
Видавництво: Baishideng Publishing Group
Серія/номер: World Journal of Diabetes;10(3):154-168.
Короткий огляд (реферат): Type 2 diabetes (T2D) is a disorder characterized by chronic inflated blood glucose levels (hyperglycemia), at first due to insulin resistance and unregulated insulin secretion but with tendency towards global spreading. The gut microbiota is recognized to have an influence on T2D, although surveys have not formed a clear overview to date. Because of the interactions between gut microbiota and host homeostasis, intestinal bacteria are believed to play a large role in various diseases, including metabolic syndrome, obesity and associated disease. In this review, we highlight the animal and human studies which have elucidated the roles of metformin, α-glucosidase inhibitors, glucagon-like peptide-1 agonists, peroxisome proliferator-activated receptors γ agonists, inhibitors of dipeptidyl peptidase-4, sodium/glucose cotransporter inhibitors, and other less studied medications on gut microbiota. This review is dedicated to one of the most widespread diseases, T2D, and the currently used antidiabetic drugs and most promising new findings. In general, the gut microbiota has been shown to have an influence on host metabolism, food consumption, satiety, glucose homoeostasis, and weight gain. Altered intestinal microbiota composition has been noticed in cardiovascular diseases, colon cancer, rheumatoid arthritis, T2D, and obesity. Therefore, the main effect of antidiabetic drugs is on the microbiome composition, basically increasing the short-chain fatty acids-producing bacteria, responsible for losing weight and suppressing inflammation.
URI (Уніфікований ідентифікатор ресурсу): http://ir.librarynmu.com/handle/123456789/241
ISSN: 10.4239/wjd.v10.i3.154.
Розташовується у зібраннях:Наукові видання кафедри ендокринології

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