Splenic hyperkinetic syndrome: a universal driver of cirrhotic and non-cirrhotic portal hypertension

Abstract

Portal hypertension (PH) is attributed to increased intrahepatic resistance. However, the role of splanchnic hyperdynamic circulation, specifically excessive inflow, remains underappreciated.We hypothesized that splenic arterial hyperperfusion acts as a universal hemodynamic driver in PH - regardless of etiology - creating a volume overload that the portal system cannot accommodate. This study aims to evaluate the relations between splenic arterial inflow and portal venous flow in patients with established cirrhotic and non-cirrhotic PH.