Early markers of renal damage in type 2 diabetes: role of vitamin D-binding protein

Abstract

Diabetic kidney damage leading to end-stage renal failure is the most frequent and prognostically unfavorable complication of diabetes mellitus. Recently, increasing attention has been focused on the extraskeletal functions of vitamin D, the role of vitamin D-binding protein (VDBP), and their pathogenetic link to kidney damage in people with type 2 diabetes. The purpose of the work is to investigate the role of VDBP as an early marker of kidney damage in individuals with type 2 diabetes and to assess the strongest correlations between early markers of kidney dysfunction in diabetic kidney disease. The search for early markers of kidney damage is a pressing task today with the increase in diabetes.