Phytodrugs combined with pharmacotherapy agents for the treatment of neurodegenerative diseases (research literature review)

Abstract

Actuality. In Ukraine and in the world as a whole, neurodegenerative diseases are widespread, the number of which is not decreasing, such as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis, multiple sclerosis. Neurodegenerative diseases arise from the neurons of the cortex and spinal cord. Each of these diseases has its own pathogenesis and classification of recommended drugs. In recent years, a certain group of these drugs is occupied by medicinal products of plant origin or their combinations with approved drugs, which helps to increase medical care for patients and makes it more targeted. The aim of the study. Identify the main existing drugs for the treatment of neurodegenerative diseases, identify herbal drugs that can be included in complex pharmacotherapy. Materials and methods. Based on the data of domestic and foreign studies on the use of medicinal products for the treatment of neurodegenerative diseases, as well as the possibility of their combination with herbal drugs according to the data of SCOPUS, “Web of Science”, Google Scholar and others, the direction of activation of the use of herbal drugs in the treatment of these diseases is shown. Research results. The pathogenesis and mechanisms of the occurrence of such diseases as Parkinson’s disease, Huntington’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis, multiple sclerosis have been determined. The main names of drugs prescribed for these diseases and their mechanisms of action are described. The main herbal drugs that can be used in neurodegenerative diseases in addition to the basic therapy in order to increase efficiency and improve the condition of patients are indicated. Conclusions. Phytodrugs are recommended to be used as concomitant treatments for Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. Focused attention on the mechanisms of action of these means. The herbal drugs that can be included in the pharmacotherapy of neurodegenerative diseases are listed.