Differences in the structural organisation of liver tissue in experimental rats 1 and 3 hours after administration of Leiurus macroctenus scorpion venom

Abstract

Scorpion bites are a serious threat to human health and life in almost all countries of the world. The amount and toxicity of the poison that enters the body of the victims depend on the interspecific variability of these animals. Scorpion venom usually causes the development of local, cardiotoxic, neurotoxic and vegetative effects. The study aimed to determine the differences in the structural organisation of the liver tissue of experimental rats 1 and 3 hours after the administration of the venom of the scorpion Leiurus macroctenus. The study was conducted on 10 male rats (200±10 g), which were injected intramuscularly with 0.5 ml of a solution of venom (28.8 μg/ml; LD50=0.08 mg/ kg) of the scorpion Leiurus macroctenus, dissolved in saline (0.9 %). The control group (10 rats) was injected with only 0.5 ml of saline (0.9 %). For microscopic examination, samples of liver tissue from animals of all groups were taken. The pieces were fixed in 10 % formalin solution for 1 day.