Chromatographic studies of drug substances: a case study in university scientific activities

Abstract

Studying natural sciences at the O.O. Bogomolets National Medical University opens up for students the opportunity to become familiar with advanced scientific discoveries, the prospect of direct participation in conducting experimental research in drug quality control laboratories. The Case study method is used to investigate a problem in a specific context and discuss how the results relate to theory. Case study is actively used in chromatographic studies of medicinal substances, during which ways of solving pharmaceutical analysis problems. The main stages of scientific experimental work according to the requirements of the Case study are determining the purpose of the study with the motivation for the need to carry out this study, motivated selection of samples for the study, drawing up a research plan with a deadline, systematization of the obtained data. In chromatographic studies, an important role is played by the selection of a large number of objects and studies, which provides a high expected increase in information and results. In chemical experiments, it is advisable to use the design of single and multiple studies to compare the results obtained with standards and the design of establishing "anomalies" to register the formation of substances. During chromatographic studies of each specific pharmaceutical object, complex approaches are developed in the analysis of substances, since similar trends are often observed in chromatographic separation, the formation of chemical degradation products. The current task remains the implementation of the Case Study learning model in the performance of scientific work by students by HPLC method.