Pathogenetic aspects of diabetes-associated osteoarthritis

Abstract

Damage to the musculoskeletal system is one of the serious, but understudied complications of diabetes mellitus (DM). Inflammatory and/or degenerative structural changes in the joints against the background of long-term hyperglycemia in the initial stages cause limitation of joint mobility, and later lead to persistent contractures and disability of patients. Therefore, the studying formation mechanisms of joint lesions in patients with DM is extremely important and relevant. The aim of our study was to identify the levels of specific hormones and biochemical markers of connective tissue metabolism in patients with diabetic arthropathy and to establish their possible influence on the development of joint pathology in this category of patients.