Транскрипційна нестабільність ядерного та мітохондріального геному як молекулярна основа спадкових захворювань

Abstract

The paper presents a review of current research on the role of DNA transcription disorders in the nucleus and mitochondria in the development of hereditary diseases. The possible consequences of transcriptional disorders for cells, including loss of gene function, mutational changes, and other molecular abnormalities, are discussed. The importance of the interaction between nuclear and mitochondrial transcription mechanisms for maintaining the energy balance of the cell and ensuring its vital activity is emphasized.