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Назва: Efficacy of Sildenafil in Patients with Severe COVID-19 and Pulmonary Arterial Hypertension
Автори: Oliynyk, O.
Rorat, M.
Strepetova, O.
Dubrov, S.
Guryanov, V.
Oliynyk, Y.
Kulivets, O.
Slifirczyk, A.
Barg, W.
Ключові слова: SARS-CoV-2; respiratory failure; pulmonary artery pressure; sildenafil
Дата публікації: 2023
Видавництво: Viruses
Короткий огляд (реферат): Pulmonary arterial hypertension (PAH) is common in severe coronavirus disease 2019 (COVID-19) and worsens the prognosis. Sildenafil, a phosphodiesterase-5 inhibitor, is approved for PAH treatment but little is known about its efficacy in cases of severe COVID-19 with PAH. This study aimed to investigate the clinical efficacy of sildenafil in patients with severe COVID-19 and PAH. Intensive care unit (ICU) patients were randomly assigned to receive sildenafil or a placebo, with 75 participants in each group. Sildenafil was administered orally at 0.25 mg/kg t.i.d. for one week in a placebo-controlled, double-blind manner as an add-on therapy alongside the patient’s routine treatment. The primary endpoint was one-week mortality, and the secondary endpoints were the one-week intubation rate and duration of ICU stay. The mortality rate was 4% vs. 13.3% (p = 0.078), the intubation rate was 8% and 18.7% (p = 0.09), and the length of ICU stay was 15 vs. 19 days (p < 0.001) for the sildenafil and placebo groups, respectively. If adjusted for PAH, sildenafil treatment significantly reduced mortality and intubation risks: OR = 0.21 (95% CI: 0.05–0.89) and OR = 0.26 (95% CI: 0.08–0.86), respectively. Sildenafil demonstrated some clinical efficacy in patients with severe COVID-19 and PAH and should be considered as an add-on therapy in these patients.
URI (Уніфікований ідентифікатор ресурсу): http://ir.librarynmu.com/handle/123456789/15025
ISSN: https://doi.org/10.3390/v15051157
Розташовується у зібраннях:Наукові публікації анестезіології та інтенсивної терапії

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