Structural changes of the intestinal epithelial barrier of the duodenum of rats in burn injury of skin under experimental streptozotocin-induced diabetes mellitus

Abstract

The aim of the study was to study the structural changes of the intestinal epithelial barrier in the duodenum in burn injury of skin in rat under experimental streptozotocin-induced diabetes mellitus. The study was carried out on laboratory white adult rats-males weighing 180-210 g. The control group consisted of 21 animals without somatic pathology, the first experimental group was 21 rats with burn skin injury, the second experimental group was 21 rats with burn skin and experimental streptozotocin-induced diabetes mellitus. The experimental diabetes model was reproduced by administering streptozotocin to the rats intraperitoneally at a single dose of 50 mg/kg. Thermal burn skin damage in rats corresponded to II - A-B degrees of dermal surface burn (according to the old classification III - A degree) with a total area of 21-23 % of the body surface with the development of burn shock.