Gut microbiome composition and frequency of small intestinal bacterial overgrowth in patients with irritable bowel syndrome with constipation and hypothyroid hashimoto’s thyroiditis: a pilot single-center, crosssectional study

Abstract

Irritable bowel syndrome (IBS) is common gastrointestinal disorder. Gut microbiome composition changes play a significant role in its pathogenesis. Hashimoto’s thyroiditis (HT) often coexists with IBS and may worsen its clinical course. Small intestinal bacterial overgrowth (SIBO) is highly prevalent in both diseases. The aim of study was to determine the gut microbiome composition and SIBO frequency in patients with IBS with constipation (IBS-C) and hypothyroid HT.