Correlation of intracardiac hemodynamics indicators with von orrelation of intracardiac hemodynamics indicators with von willebrand factor – marker of endothelial dysfunction in patien illebrand factor – marker of endothelial dysfunction in patients with coronary artery disease combined with coronavirus disease ith coronary artery disease combined with coronavirus disease (COVID-19)

Abstract

The research aims to establish the relationship between indicators and the role of endothelial dysfunction in the pathogenesis of various conditions. The clinical observation method was used, and data such as symptoms, medical history, and laboratory and instrumental studies were collected. The study revealed an increased activity of von Willebrand factor (vWF) in the majority of patients. When comparing groups of patients depending on the presence of concomitant coronavirus disease, it was found that the highest level of vWF was observed in patients with coronary heart disease in combination with coronavirus disease, a lower level in patients with coronavirus disease alone, and the lowest level in patients with chronic coronary heart disease. This indicates a correlation between the level of vWF and the presence of concomitant coronavirus disease, which emphasises the importance of vascular endothelial dysfunction in the pathogenesis of coronary heart disease. It was found that the value of the vWF correlates with the left ventricular enddiastolic size in both patients with coronary heart disease and patients with coronary heart disease in combination with coronavirus disease. This demonstrates that there is a strong association between vWF and the clinical manifestation of coronary heart disease in combination with coronavirus disease, which may indicate a dysfunction of the vascular endothelium in these patients.