Estimation Of Prognostic Significance Of Pelvic Organ Prolapse Predictors After Hysterectomy In Menopausal Transition Period

Abstract

The article presents a statistical analysis of the data on the prognostic significance of such predictors of pelvic organ prolapse as vaginal delivery, parity, surgical or traumatic delivery, age at menopausal transition, overweight and obesity, hysterectomy, stigma of undifferentiated connective tissue dysplasia, and the rs1800012 polymorphism of the procollagen type I alpha (α) 1 COLIA1 gene. The study examined 60 patients with pelvic organ prolapse of the third and fourth degree (according to the POP-Q classification) and 60 women without pelvic floor dysfunction. We used the chi-square single-factor analysis method to assess the possible impact of each factor. To determine the combined effect of all factors on the risk of pelvic organ prolapse, binary logistic regression was used to calculate the odds ratio. Results with p<0.05 were considered statistically significant. High vaginal delivery parity (OR: 2.569; 95% CI: 1.106-5.967), genetically determined undifferentiated connective tissue dysplasia (OR: 3.788; 95% CI: 1.664- 8.624), hysterectomy (OR: 2.569; 95% CI: 1.106-5.967), and age over 50 (OR: 2.380; 95% CI: 1.050-5.393) demonstrate an etiological link with the development of pelvic organ prolapse, and their combined effect increases the risk of pelvic organ prolapse.