Будь ласка, використовуйте цей ідентифікатор, щоб цитувати або посилатися на цей матеріал: http://ir.librarynmu.com/handle/123456789/1228
Назва: The study of leukocyte phagocytic activity in the presence of herpetic infection and stroke
Автори: Motorna, Natalia
Rybalko, Svetlana
Starosyla, Daria
Guzyk, Mykhailo
Strokina, Iryna
Kaminsky, Rostyslav
Korsak, Alina
Savosko, Sergey
Sokurenko, Liudmyla
Chaikovsky, Yurii
Ключові слова: stroke
herpes simplex virus type I
leucocytes
acyclovir
proteflazid
altabor.
Дата публікації: 2018
Видавництво: Wydawnictwo Aluna
Серія/номер: LXXI;1
Короткий огляд (реферат): Inrtoduction: Post-stroke complications are one of the urgent and insufficiently resolved problems. According to different literature data 23% to 65% of patients suffer from the post-stroke development of an infectious process. Herpes simplex virus type 1 and 2 can also be etiological factors of stroke development, however their reactivation is seldom mentioned in clinical observations. The development of immune suppression is considered to be the cause of these complications. The aim: The current study aims at determining post-stroke changes in leukocyte component of the immunity and in the presence of concomitant herpetic infection as well as at finding changes in phagocytosis parameters during antiviral treatment. Materials and methods: The experiments were carried out on mice of the Balb/с line. The animals were infected with the herpes simplex virus type I, and 30 days later hemorrhagic stroke was simulated by administering 0.1 ml of autoblood into the right hemisphere. Following the acute stroke some animals were given acyclovir, proteflazid or altabor. From the animals’ blood leukocytes were obtained and phagocytic activity and production of reactive oxygen species of granulocytes and agranulocytes in relation to fluorescent E.coli bacteria were studied by flow cytometry. Results: The experiment revealed significant changes in the redistribution between two major types of leukocytes in mice with stroke (an increased number of agranulocytes by 19.9%) and decreased phagocytosis activity, in the animals infected with herpes simplex virus type І in particular. Ischemic brain damage had an immunosuppressive effect on blood leukocytes. For comparison a significant increase in phagocyte count in leukocytes was found in the case of viral infection. The use of drugs with antiviral effects did not affect the activity of granulocytes / agranulocytes. Conclusion: Stroke can be the cause of latent herpes virus infection reactivation and has essential negative effect on immune characteristics of leukocytes that remain unchanged with the use of antiviral agents
URI (Уніфікований ідентифікатор ресурсу): http://ir.librarynmu.com/handle/123456789/1228
Розташовується у зібраннях:Наукові публікації кафедри анатомії людини

Файли цього матеріалу:
Файл Опис РозмірФормат 
THE STUDY OF LEUKOCYTE PHAGOCYTIC ACTIVITY IN THE.pdf1,26 MBAdobe PDFПереглянути/Відкрити


Усі матеріали в архіві електронних ресурсів захищені авторським правом, всі права збережені.