Both Maternal And Newborn Igms Inhibit Transmissible Gastroenteritis Virus Internalization In LLC-PK1 Cells

Abstract

Immunoglobulins M (IgMs) are the evolutionally oldest class of antibodies in higher eukaryotes. This pool of antibodies is one of the first to appear in humans and begins to besynthesized at the early stages of the neonatal period. Most of the repertoire of IgMs of the newborns consists of the so-called «natural», or «naive», antibodies synthesized by the body without external antigenic stimulation. In addition to the classical functions of human immunoglobulins M (such as antigen recognition and initiation of innate immune responses), antibodies of this class exhibit a variety of non-canonical functions. The non-canonical functions are the action of antibodies as agonists/antagonists of various receptors, cleavage of antigen due to the catalytic activity of IgM, direct inactivation of pathogens in the absence of eff ector cells and molecules, etc.