Study of the degree of dysbiosis in the oral fluid of patients following surgical tumour removal and chemotherapy during the application of a therapeutic and preventive complex

Abstract

The study aimed to evaluate the effect of a therapeutic and preventive complex on the degree of dysbiosis in the oral fluid of patients following surgical removal of head and neck tumours and chemotherapy. Thirty-five adults aged 25–55 years were examined: 10 healthy controls, 10 patients receiving standard oncological care, and 15 patients receiving standard care combined with the proposed complex. The degree of dysbiosis was calculated from the ratio of relative urease and lysozyme activities in oral fluid at baseline and after 1, 3, 6, and 12 months. At baseline, the indicator exceeded the reference value approximately 15-fold in both patient groups. Standard treatment produced only a partial and temporary reduction. In the main group, the degree of dysbiosis decreased 1.7-, 4.1-, 6.5-, and 9.3-fold after 1, 3, 6, and 12 months, respectively, approaching the physiological range. The proposed complex promoted sustained restoration of oral microbial homeostasis.