Influence of silica gel, containing nanoparticles of gold and silver, on the biochemical indices of the experimental inflammation of oral mucosa

Abstract

Aim: to study the influence of drugs containing nanoparticles of gold and silver on the biochemical markers of inflammation and dysbiosis, under the experimental conditions on the inflammation model of the oral mucosa of rats. Materials and methods: the study was conducted on 42 white rats, in which the inflammation of the oral mucosa was experimentally induced by the use of Lipopolysaccharide (LPS). The preliminary application, on the oral mucosa, of the gel containing gold and silver nanoparticles was done 2 days before the experimentallyinduced inflammation. The activity of the biochemical indices of inflammation was determined in the homogenate of gingiva and cheek mucosa. Results and disscusion: Application of Lipopolysaccharide LPS on the rat oral mucosa caused the growth of elastase activity and MDA content, as a sign of inflammation. Application of gels containing Lyzomucoid with nanoparticles of gold and silver reduced the level of biochemical markers of inflammation, but only in the buccal mucosa. Catalase activity, decreased under the action of LPS, significantly increased in both gingiva and buccal mucosa. Conclusions: The gel containing Lyzomucoid preparations and nanoparticles of gold and silver significantly increases the activity of catalase and the antioxidant-prooxidant index (IPA) in both tissues. Decreased levels of oral mucosa dysbiosis were recorded.