Neuropeptide dalargin: therapeutic potential

Abstract

The main aim of the article is to draw attention to the real therapeutic potential of the neuropeptide dalargin as a remedy of radiological pharmacology as part of the repurposing of drugs, to give some examples of its clinical use that are not covered by domestic reviews. Dalargin is a synthetic analogue of the endogenous regulatory neuropeptide leucine-enkephalin and has the following structure: TyrD-Ala-Gly-Phe-Leu-Arg. The drug to some extent has wound healing, reparative, anti-inflammatory, antioxidant, lymphogenic, hypotensive, antiarrhythmic, endothelioprotective, cardioprotective, pulmoprotective, hepatoprotective, pancreatoprotective, hypocholesterolemic, antiatherosclerotic, antihypoxic, antiischemic, analgesic, antidepressant, antistress, immunomodulatory, anticarcinogenic, antitumor, antimetastatic, arteriolo- and venulodilating action; normalizes the activity of neuroendocrine subsystems: hypothalamic-pituitary-adrenal, sympathetic-adrenal; increases the glomerular filtration rate of the kidneys, significantly reduces the release of pro-inflammatory cytokines, prevents the development of acute respiratory distress syndrome [1,3,4, 6-18, 20-23]. The list of effects of dalargin makes it possible to formulate and predict new effects not listed above. Described usage of dalargin in diagnostic tests for MRI, perfusion single photon emission computed tomography and echocardiography, in the treatment of combined radiation injuries. Dalargin should be used to prevent the development of pathological processes / conditions in personnel when working in extreme conditions and in patients with comorbidity in surgery, combustiology, dentistry, oncology and traumatology. Key words: dalargin, MRI, single-photon emission computed tomography, combined radiation injuries, stress-induced disorders, wound healing, burns.