Smoking in adolescents as a factor in the development of dys regenerative processes in the gastric mucosa

Abstract

We observed 47 adolescents with chronic gastritis who smoke. To verify the diagnosis of chronic gastritis, all adolescents underwent esophagogastroduodenoscopy with biopsy of the gastric mucosa for further morphological and immunohistochemical examination. Based on the study, morphological changes of gastric mucosa were established, which are pathognomonic for chronic gastritis in active teenagers-smokers: lymphocytes plasma-cells infiltration, focal destruction of glands, hypotrophia and microcirculatory changes of the stomach mucosa membrane. Immunohistochemical indexes of cellular restoration are characterized by increased indexes of proapoptotic and decreased proliferative activity. To sum up, microcirculatory and dysregenerative disorders of the gastric mucosa are associated with the negative impact of nicotine.