Prognosis of the formation and diagnosis of undifferentiated connective tissue dysplasia to assess the further child wellbeing

Abstract

Analysis of perinatal anamnesis of 590 children ages from 3–14 years old with the help of a specially designed computerized information retrieval system made it possible to detect and verify the leading pathology in pregnant women contributed to the formation of uCTD syndrome: the presence of 2 or more leading adverse conditions (prematurity, toxicosis in the first trimester of pregnancy, high risk of miscarriage, autonomic dysfunction in the mother in the first half of pregnancy, birth by Caesarean section), are prognostic for the birth of a child with uCTD syndrome. Significant changes found in the health status of children with uCTD syndrome increased with age, which was strongly associated with increased collagen breakdown (according to the levels of hydroxyproline and glycosaminoglycans in the urine), impaired immunity (decrease in indicators of local immunity immunoglobulins (Ig) - IgA and sIgA in saliva), phagocytosis (phagocytosis activity and oxygen-dependent neutrophil metabolism) and activation of lipid peroxidation. The conducted research confirms the expediency of introducing the appropriate background condition of uCTD syndrome manifestations of syndromic pathology and associated diseases into a letter of the specified diagnoses of the polyclinic card (health records) of the child's development