Substantiation of the need for monitoring in environmental objects of insecticides from the class of tetramic and tetronic acid derivatives taking into account their specific influence on the human organism

Abstract

The aim: Substantiation of the need for monitoring in environmental objects of spiromesifen, spirodiclofen and spirotetramat, taking into account their specific impact on the human organism to reduce the risk of their negative influence on public health and the environment. Materials and methods: The subject was insecticides, the class of tetramic and tetronic acids derivatives, spiromesifen, spirodiclofen and spirotetramate. Physico-chemical, toxicological and hygienic evaluation of the results was performed according to the literature data. Selection criteria were used to substantiate the needs in monitoring of these insecticides. Results: Spiromesifen, spirodiclofen and spirotetramate according to the Hygienic classification of pesticides by the limiting criterion of hazard belong to 1 class (strong allergen), 2 (carcinogen) and 3 classes (inhalation toxicity), respectively. The value of ADD (allowable daily dose) for human of spiromesifen, approved in Europe is 0.03 mg•kg-1. According to the assessment of hazards for professional contingents and the coefficient of possible inhalation poisoning (CPIP) and the coefficient of selective action (CSA), spiromesifen may pose a risk. We can conclude about the safety of the compound according to GUS, SCI-GROW, LEACH indices, and hence the absence of risk of potential entry of the substance into the human body with contaminated water or food. According to persistence in the environment, these insecticides are law and moderately persistent. Direct effect on the thyroid gland is absent. Conclusions: Monitoring of spiromesifen and spirotetramate in water, soil and agricultural raw materials is not obligatory, and for spirodiclofen is desirable.