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dc.contributor.authorOliynyk, O.-
dc.contributor.authorBarg, W.-
dc.contributor.authorSlifirczyk, A.-
dc.contributor.authorOliynyk, Y.-
dc.contributor.authorGurianov, V.-
dc.contributor.authorRorat, M.-
dc.date.accessioned2023-05-19T08:49:38Z-
dc.date.available2023-05-19T08:49:38Z-
dc.date.issued2021-
dc.identifier.urihttp://ir.librarynmu.com/handle/123456789/7605-
dc.description.abstractAbstract: Background: Cytokine storm in COVID-19 is heterogenous. There are at least three subtypes: cytokine release syndrome (CRS), macrophage activation syndrome (MAS), and sepsis. Methods: A retrospective study comprising 276 patients with SARS-CoV-2 pneumonia. All patients were tested for ferritin, interleukin-6, D-Dimer, fibrinogen, calcitonin, and C-reactive protein. Ac cording to the diagnostic criteria, three groups of patients with different subtypes of cytokine storm syndrome were identified: MAS, CRS or sepsis. In the MAS and CRS groups, treatment results were assessed depending on whether or not tocilizumab was used. Results: MAS was diagnosed in 9.1% of the patients examined, CRS in 81.8%, and sepsis in 9.1%. Median serum ferritin in patients with MAS was significantly higher (5894 vs. 984 vs. 957 ng/mL, p < 0.001) than in those with CRS or sepsis. Hypofibrinogenemia and pancytopenia were also observed in MAS patients. In CRS patients, a higher mortality rate was observed among those who received tocilizumab, 21 vs. 10 patients (p = 0.043), RR = 2.1 (95% CI 1.0–4.3). In MAS patients, tocilizumab decreased the mortality, 13 vs. 6 patients (p = 0.013), RR = 0.50 (95% CI 0.25–0.99). Conclusions: Tocilizumab therapy in patients with COVID-19 and CRS was associated with increased mortality, while in MAS patients, it contributed to reduced mortality.uk_UA
dc.language.isoenuk_UA
dc.publisherWiadomości Lekarskieuk_UA
dc.subjectmonoclonal antibodies; ARDS; cytokine storm syndrome; inflammationuk_UA
dc.titleEfficacy of tocilizumab therapy in different subtypes of covid-19 cytokine storm syndromeuk_UA
dc.typeArticleuk_UA
Розташовується у зібраннях:Наукові публікації кафедри менеджменту охорони здоров’я післядипломної освіти

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