Metabolism of lipids in plasma and blood erythrocytes in patients with severe pulmonary tuberculosis, its features

Abstract

103 healthy individuals (group I) and 62 patients with severe pulmonary tuberculosis (group II) were examined. The composition of fatty acids was determined using a biochemical method on a gas-liquid chromatograph "Cvet - 500" with a plasma ionization detector in isothermal mode. It was found that in healthy individuals the composition of fatty acids is unidirectional in plasma and erythrocytes. The analysis of researches showed disturbances of metabolism of higher fatty acids in plasma and erythrocytes of blood at patients with pulmonary tuberculosis with a severe course. In patients with severe pulmonary tuberculosis, the composition of fatty acids changes unidirectionally in plasma and erythrocytes: there is a significant increase in the total content of saturated fatty acids on the background of reduced total content of unsaturated and polyunsaturated fatty acids. In patients with severe pulmonary tuberculosis, multidirectional changes in the level of arachidonic fatty acid were found: in erythrocyte biomembranes the content decreased, in blood plasma – increased (p < 0.05).