Early endoscopic photodynamic diagnosis of colonic lesions

Abstract

Aim: The aim of the study is to improve the quality of early endoscopic verification of aplastic changes of the colonic mucosa by use of the photodynamic diagnosis method. Material and methods: The study is based on 2,817 video colonoscopies; bioptates were taken in 1,206 cases, representing 43% of the total number of endoscopic examinations. In 72 patients (44 males and 28 female) with neoplasia of the colon videocolonoscopic examination using the photodynamic diagnostics method was performed. Results: The results of endoscopic examination using the method of photodynamic diagnosis of 72 patients (44 male and 28 female) with neoplasia of the colon are presented. The method of photodynamic diagnostics is based on the differences of the autofluorescence spectra, which is characteristic for the unchanged mucous membrane of the colon (λmax= 535-565 nm) and induced by the photosensitizer of fluorescence of morphologically atypical cells (λmax=595-640 nm). Conclusions: The use of photodynamic diagnostics allowed to increase the accuracy, sensitivity and specificity of neoplastic processes of the colonic mucosa verification to 97.1%, 94.9% and 94.2%, accordingly, and the frequency of coincidence of endoscopic and pathohistological diagnoses 95.2%.