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dc.contributor.authorІоффе, О. Ю.-
dc.contributor.authorОмельченко, А. В.-
dc.contributor.authorГончаров, С. В.-
dc.contributor.authorСтрой, Д. О.-
dc.contributor.authorДроздовська, С. Б.-
dc.contributor.authorСтеценко, О. П.-
dc.contributor.authorКривопустов, М. С.-
dc.contributor.authorДіброва, Ю. А.-
dc.contributor.authorГалига, Т. М.-
dc.contributor.authorВасильєв, А. В.-
dc.contributor.authorПерепадя, В. М.-
dc.contributor.authorТарасюк, Т. В.-
dc.contributor.authorДосенко, В. Є.-
dc.date.accessioned2023-02-13T11:18:05Z-
dc.date.available2023-02-13T11:18:05Z-
dc.date.issued2020-
dc.identifier.issn2522-9028-
dc.identifier.urihttp://ir.librarynmu.com/handle/123456789/6235-
dc.description.abstractSports hernias are diagnosed in over 80% of athletes presenting with chronic groin pain. The genotype distributions of the examined polymorphisms were studied in 95 football players, all males, using the Copenhagen Hip and Groin Outcome Score (HAGOS) questionnaire. DNA extracted from buccal epithelium. Statistical calculations were performed in the R statistical environment (r-project.org) and Odds ratios (OR) were used to estimate genotype associations. Multifactor dimensionality reduction was used to identify multiple sports hernia susceptibility loci.Two single nucleotide polymorphisms MCT1 rs1049434 and COL1A1 rs1800012 are associated with sports hernias (63% testing accuracy shown by random forest). According to the HAGOS questionnaire outcomes, exercise-related pain, reduced mobility, and range of motion in the groin and thigh are typically associated with sports hernia diagnosis (75% testing accuracy shown by random forest).The combination of genetic research and HAGOS questionnaire helped obtain a sensitivity of 93% for the detection of sports hernia. Active engagement in sport is the most important risk factor for sports hernia, so the identification genes SNP in footballers may contribute to taking timely preventive actions. This study is the first demonstration of an association between sports hernia and COL1A1 rs1800012 genotype. The study discovered a synergistic interaction between the indicated polymorphism and the gene polymorphism MCT1 rs1049434. Further investigations are required to study the association between COL12A1 rs240736 gene SNP and sports hernia.uk_UA
dc.language.isoenuk_UA
dc.publisherФізіологічний журналuk_UA
dc.relation.ispartofseries66;6-
dc.subjectsingle nucleotide polymorphismuk_UA
dc.subjectgeneticsuk_UA
dc.subjectsports herniauk_UA
dc.subjectfootball playeruk_UA
dc.subjectCOL1Auk_UA
dc.subjectMCT1uk_UA
dc.subjectCOL12A1uk_UA
dc.titleAssoсiation analysis of gene polymorphisms COL1A, MCT1, COL12A1 with sports hernia in football playersuk_UA
dc.typeArticleuk_UA
Розташовується у зібраннях:Наукові публікації кафедри загальної хірургії №2

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