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dc.contributor.authorGychka, S.-
dc.contributor.authorBrelidze, T.-
dc.contributor.authorKuchyn, I.-
dc.contributor.authorSavchuk, T.-
dc.contributor.authorNikolaienko, S.-
dc.contributor.authorZhezhera, V.-
dc.contributor.authorChermak, I.-
dc.contributor.authorSuzuki, Y.-
dc.date.accessioned2023-02-08T08:32:19Z-
dc.date.available2023-02-08T08:32:19Z-
dc.date.issued2022-
dc.identifier.urihttp://ir.librarynmu.com/handle/123456789/5897-
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 has been causing the pandemic of coro navirus disease 2019 (COVID-19) that has so far resulted in over 450 million infections and six million deaths. This respiratory virus uses angiotensin-converting enzyme 2 as a recep tor to enter host cells and affects various tissues in addition to the lungs. The present study reports that the placental arteries of women who gave birth to live full-term newborns while developing COVID-19 during pregnancy exhibit severe vascular wall thickening and the occlusion of the vascular lumen. A morphometric analysis of the placental arteries stained with hematoxylin and eosin suggests a 2-fold increase in wall thickness and a 5-fold decrease in the lumen area. Placental vascular remodeling was found to occur in all of SARS-CoV-2-positive mothers as defined by RT-PCR. Immunohistochemistry with α smooth muscle actin and the Kv11.1 channel as well as Masson’s trichrome staining showed that such placental vascular remodeling in COVID-19 is associated with smooth muscle proliferation and fibrosis. Placental vascular remodeling may represent a response mechanism to the clinical problems associated with childbirth in COVID-19 patients.uk_UA
dc.titlePlacental vascular remodeling in pregnant women with COVID-19uk_UA
dc.typeArticleuk_UA
Розташовується у зібраннях:Наукові публікації кафедри патологічної анатомії

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