Мутации в генах IDH1 и IDH2 у пациентов с впервые выявленной острой миелоидной лейкемией: роль в лейкогенезе, частота возникновения, ассоциация с прогнозом

Abstract

Abstract. Acute myeloid leukemia (AML) is a malignant hematologic disease characterized by clonal proliferation of myeloid blasts in the peripheral blood, bone marrow and their further accumulation in organs and tissues due to congenital or acquired genetic mutations. Mutations in the IDH1/2 genes represent a new class of point mutations in patients with AML. The prognostic effect of this mutations is the subject of research and so far remains controversial. The aim of this study is to present the overview of modern clinical literature in order to better understanding biochemistry, mechanisms of leukogenesis and influence of these class of mutations on prognosis and clinical outcome of patients with AML