Зміни у корі півкуль великого мозку за умов моделювання ішемії та імунокорекції (імуногістохімічне дослідження)

Abstract

In conditions of cerebrovascular damage, in the sensorimotor cortex, a complex changes in the immunohistochemical markers expression has been shown.It reflect the functional status of neurons or and the state of their cytoskeleton, and it her the state of neuroglia markers. For the first time a quantitative estimate of changes in the expression of these markers, their dynamics after transient ischemic attack, including in the long term after the violation of blood supply to the brain it has been estimated. It shown that diffuse changes caused by ischemic damage in sensorimotor cortex are transformed into slowly progressing neurodegenerative process with signs of neuroinflammation and development of astrocytosis. It shown that ischemic lesion of the left hemisphere is accompanied by systemic reactions of neuroglia, which extends to the contralateral hemisphere. It is has been shown that previous sensitization by brain antigen potentiates changes in the expression of immunohistochemical markers that causes ischemia, as well as modifies their dynamics. Immunocorrection of changes in the sensorimotor cortex under conditions of ischemia and in the context of a complex immune-vascular lesion in an experiment evaluated by the expression of immunohistochemical markers leads to a decrease in both the severity of the altered phenomena and the relative activation of the compensatory-recovery processes in the sensorimotor cortex.