Local application of nonsteroidal anti-inflammatory drug in the treatment of erosive and ulcerative lesions of the oral mucosa

Abstract

Summary. Aim. To increase the effectiveness of treatment of erosive and ulcerative lesions of the oral mucosa with the use of NSAIDs for local application. Materials and methods. We observed 59 patients aged 25--59 years, of which 27 men and 32 women. 18 patients were diagnosed with acute mechanical injury, 13 -- erosive and ulcerative form of leukoplakia, 8 -- chronic recurrent stomatitis, 9 -- necrotizing ulcerative stomatitis, 7 -- erosive and ulcerative form of lichen ruber planus and 4 -- infectious -allergic form of erythema multiforme. All patients were carried outclinical and laboratory examinations and prescribed treatment according to the protocol of treatment of erosive and ulcerative lesions of the oral mucosa. As NSAID drug for local application we used Tantum Verde®. Results. At 1-3 days of treatment significantly intensity of pain was decreased or disappeared completely. Reduction in the degree of pain depended on severity of inflammation around the centers of erosion and ulcers in many ways. In addition, a decrease in hyperemia and swelling of the oral mucosa, and hypertrophy of the lymph nodes when applying benzydamine was observed from the 1st day of treatment. Conclusion. As a result of clinical studies aimed at improving the treatment of patients with erosive and ulcerative lesions of the oral mucosa with the topical application of non-steroidal anti-inflammatory drugs a decrease in the intensity and reduction of the pain syndrome, accelerating the process of cleaning erosive ulcerous surface from the fibrinous plaque relief of inflammation and reduction of terms of epithelialization lesions of the oral mucosa were observed, and the rehabilitation period proceeded smoothly and quickly. Keywords: erosive and ulcerative lesions of the mucous membrane, non-steroidal anti-inflammatory drugs, Tantrum Verde, benzydamine.