Влияние гормонального контрацептива на состояние пародонта крыс

Abstract

Abstract. Pregnant women often develop periodontal lesions, in the form of gingivitis, which are associated with hyperestrogenia. Hormonal contraceptives also contain estrogens, which can provoke inflammatory periodontal disease. The aim of the study: a study of the possible periodontopathogenic effect of the combined oral contraceptive "Yarina" Materials and methods of research. The experiments were performed on 14 white rats. Each rat received 0.7 g of oral contraceptive. In the whole blood of rats, the content of hemoglobin, erythrocytes, leukocytes and leukocyte formula was determined [5], in the serum - protein content, urease activity [6], lysozyme [7], elastase [8], catalase [8] and malonic dialdehyde content MDA) [9]. In the gum homogenate, the activity of urease, lysozyme, elastase, catalase, and MDA content was also determined. Results. In the blood of rats there is a tendency to increase the level of lymphocytes and monocytes; The activity of elastase increases, the activity of urease decreases, the activity of alkaline phosphatase decreases and the mineral index decreases. In rats receiving a contraceptive, there is a tendency to increase the degree of bone atrophy of the alveolar process. Conclusions. Prolonged use of the contraceptive "Yarina" causes the development of inflammation in the periodontium and systemic inflammation in the serum. Keywords: periodontium, experimental study, oral contraceptives