Kidney ureaplasmosis in terms of evidence medicine (experimental study)

Abstract

Our aim was to create an experimental model of pyelonephritis in animals using Ureaplasma parvum and to examine the histology of renal pathological process as well as its biochemical and immunological characteristics. Modeling of the rabbits’ medical condition was based on V. Pratt method in our own adaptation. Observation was conducted for over 90 days with the studying of biochemical and immunological indices changes. Using U.parvum when creating pyelonephritis experimental model in rabbits caused the development of the kidney lymphoid cell infiltration, microcirculation disorders, stroma swelling, initial vessels and interstitium sclerosis as well as the development of the degenerative changes in the epithelium of the kidney tubular system and urothelium bladder. Animals infected with ureaplasma had hematogenous dissemination of the pathogen in different organs and generalized ureaplasmic infection, which caused systemic immune response in the form of specific antibodies titres increasing to ureaplasma. We proved the development of systemic inflammation in the greater part of parenchymal organs (uterus, liver, lungs, heart, thyroid gland) with the most florid onset in the infected kidneys and lungs. Biochemical indices time course reconstituents a pattern of changes in the kidneys, bladder, liver, lungs, uterus and other organs. U.parvum should be considered as a predictor of acute inflammation of a kidney and urinary tract caused by classical bacteria on the one hand and a development of pathological changes that can be considered as a primary chronic inflammatory process, which differs from the bacterial on the other.