Morphofunctional features of renal glomerular capillaries in conditions of congenital hypothyroidism in the age aspect

Abstract

Blood capillaries of rat renal glomeruli were studied 14, 50 and 100 days after the development of congenital hypothyroidism. It was found that on day 14 after the onset of hypothyroidism 7-day-old rats had a decrease in morphometric parameters of the number of capillaries and their area in comparison with age control in the absence of any marked morphological changes. In 45-day-old rats 50 days after the development of this pathology in glomerular blood capillaries changes in quantitative indicators had not reached critical values, while the presence of both destructive-dystrophic and compensatory processes were noted morphologically. 100 days after the development of pathology changes in blood capillaries became more pronounced than in the previous period. Destructive-dystrophic changes of a part of capillaries and the phenomena of necrosis and apoptosis were observed in the presence of compensatory-adaptive processes