Cardiovasotoxic effect of different sizes lead nanoparticles introduction

Abstract

Cardiovascular toxicity of Pb compounds NP (nanoparticles) 26-34 nm and 50-80 nm in size was investigated in the experiments. Morphological and morphometric methods were used to detect structural changes in the heart and aorta after 30 and 60 injections of Pb compounds NP. The results of the experiments indicate damage to the myocardium, which consists in increasing of the interstitial space between the fibers of cardiomyocytes, dystrophy of cardiomyocytes, stasis of blood in the microvessels of the heart` ventricles. A greater sensitivity of the atrial myocardium to the toxic effects of Pb compounds NP was detected. Structural changes of the aorta consisted in a stratification of elastic membranes, a decrease in the density of the connective tissue of the adventitious layer, which tended to progressive changes.