Воздействие композиции биоактивной стеклокерамики модифицированного состава на репарацию экспериментального костного дефекта

Abstract

For investigation bone reparative activity of the modified bioactive glass-ceramic composite in combination with the glycosaminoglycans in vivo study was applied. The modeled rat’s mandibular bone defects were restored by the compositions of materials. Bovine Swiss bone graft material has been chosen for the comparison. The activity of alkaline phosphatase (AlP), acid phosphatase (AP), general proteolytic activity, content of soluble proteins (Prot.), as well as contents of calcium (Ca) and phosphorus were determined in homogenates of osseous tissue from healing areas during 10 and 30 days. In the experimental bone defect model activity of phosphatases and proteases was enhanced as well as calcareous content was decreased. The held investigations have shown the ability such bioglass ceramics to stimulate the processes of osteogenesis, influencing, mainly, the mineralizing function, about which the growth of the index AlP/AP and the ratio Ca/Prot. speak. It was suggested that the proposed composition is not worse than more expensive bovine bone grafting material.